Effect of statin treatment on mortality in a large cohort of heart failure patients.

We studied 3162 heart failure patients included in the Spanish BADAPIC registry in order to determine whether statin treatment influences prognosis. Patients were followed up for 35 +/- 22 months (median, 32 months). Patients on statins were more often male and had higher prevalences of risk factors, ischemic heart disease and systolic dysfunction (P< .001) than those not on statins. After adjustment for age, risk factors, ischemic heart disease, renal failure, ejection fraction, anemia, heart rate and drug treatment, statin treatment was found to be a favorable independent predictor of survival: the hazard ratio for mortality was 0.73 (95% confidence interval, 0.45-0.88; P< .001). During follow-up, the 3-year survival rate was higher in patients treated with statins (75% vs. 68%; P< .001). In patients with heart failure, statin treatment appears to be independently associated with better survival.